Smokers and negative smokers are exposed to a probable carcinogen named furan formed during tobacco burning. The purpose of this investigation was to assess the protective role of two natural antioxidants, naringin and propolis against furan-induced hepatocyte damage in rat livers. Rats were divided into 7 groups: control group; furan group (40 mg/kg b.w furan); furan + narnigin 50 (40 mg/kg b.w furan and 50 mg/kg narnigin); furan + narnigin 100 (40 mg/kg b.w furan and 100 mg/kg narnigin); furan + propolis 100 (40 mg/kg b.w furan and 100 mg/kg propolis); furan + propolis 200 (40 mg/kg b.w furan and 200 mg/kg propolis); furan + silymarin (40 mg/kg b.w furan and 37.8 mg/kg b.w silymarin); all treatments administrated orally for 28 days. Blood samples were obtained at the end of experiment for biochemical determination of hepatic enzymes, protein and lipid profiles. Furan administration leads to increasing in hepatic enzyme activities, reducing in albumin and total protein levels, and increasing in serum total cholesterol in addition to triacylglycerols compared to control group. In groups treated with narnigin (50 and 100 mg/kg) and propolis (100 and 200 mg/kg) the biochemical alterations induced by furan were significantly ameliorated compared to furan group. Interestingly, low dose of narnigin showed the closest results to silymarin treated group. Moreover, the high dose of propolis was more efficient than low dose compared to silymarin group. Thus, using narnigin and propolis as natural antioxidants markedly ameliorate adverse effects of furan.