ManageChatDiscover
273168

The combined protective effect of N-acetylcysteine and vitamin E against acrylamide-induced nephrotoxicity in rats

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pharmacology

Abstract

The purpose of this study was to see if N-acetylcysteine (NAC) and/or Vitamin E (Vit E) could help rats with renal damage caused by acrylamide (ACR). The antioxidant and nephroprotective efficacy of NAC and Vit E against ACR-induced nephrotoxicity in rats was investigated in this workThe rats were assigned to seven groups (each with seven rats): control vehicle group (saline only), NAC group (150 mg/kg, orally), Vit E group (100 mg/kg, orally), ACR group (20 mg/kg, orally), NAC+ACR group, Vit E+ACR group, and NAC+Vit E+ACR group. Creatinine, urea, and glucose concentrations in the blood rose as a result of ACR. Furthermore, ACR reduced protein and albumin levels. Malondialdehyde levels in kidney tissues increased dramatically as reduced glutathione, superoxide dismutase, and catalase levels decreased. ACR also caused certain degenerative lesions in the kidney tissues and elevated caspase-3 expression. NAC and Vit E, either alone or in combination reduced kidney toxicity and apoptosis caused by ACR.

DOI

10.21608/bvmj.2022.146800.1537

Keywords

N-acetylcysteine, Caspase-3, acrylamide, Renal toxicity, Vitamin E

Authors

First Name

Shimaa

Last Name

taima

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt.

Email

mohamedhafez19@yahoo.com

City

-

Orcid

-

First Name

Faten

Last Name

Elsayed

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt.

Email

fatenelsayed@yahoo.com

City

-

Orcid

-

First Name

Mahmoud Abdelghaffar

Last Name

Emam

MiddleName

-

Affiliation

Histology Dept., Faculty of Veterinary Medicine, Benha University

Email

mahmoud.hussein@fvtm.bu.edu.eg

City

Tukh

Orcid

-

First Name

samar saber

Last Name

Ibrahim

MiddleName

-

Affiliation

forensic medicine and toxicology, faculaty of veterinary medicine , benha university

Email

samar.mohamed@fvtm.bu.edu.eg

City

-

Orcid

0000-0001-5530-9521

First Name

Mohamed

Last Name

Aboubakr

MiddleName

-

Affiliation

Department of pharmacology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt

Email

mohamed.aboubakr@fvtm.bu.edu.eg

City

-

Orcid

-

Volume

42

Article Issue

2

Related Issue

37149

Issue Date

2022-09-01

Receive Date

2022-06-24

Publish Date

2022-09-01

Page Start

109

Page End

113

Print ISSN

1110-6581

Online ISSN

2974-4806

Article File

BVMJ_Volume 42_Issue 2_Pages 109-113.pdf

PDF . 1.1MB

Link

https://bvmj.journals.ekb.eg/article_273168.html

Detail API

https://bvmj.journals.ekb.eg/service?article_code=273168

Order

273,168

Type

Original Article

Type Code

812

Publication Type

Journal

Publication Title

Benha Veterinary Medical Journal

Publication Link

https://bvmj.journals.ekb.eg/

MainTitle

The combined protective effect of N-acetylcysteine and vitamin E against acrylamide-induced nephrotoxicity in rats

Details

Type

Article

Created At

22 Jan 2023