Hyper or Hypothyroidism are an overactive or underactive thyroid gland that prevents the body from operating properly. The potential therapeutic effects of spirulina platensis and GSPE on experimental hypothyroidism and hyperthyroidism in rats were evaluated.A total 96 rats were split into two main experimental groups: Experiment A: carbimazole-induced hypothyroidism(1.8mg/kg b.wt) and experiment B: - induced hyperthyroidism(50, 100, 200ug/kg b.wt) for the first three weeks, respectively.The administered GSPE dose (150/kg b. wt/day) and Spirulina (300mg/kg b. wt/day) for 3 weeks.The Hyperthyroidism experiment (A)six sets of rats were used: Group 1(control normal), Group 2(hyperthyroidism),Group3 (GSPE Protected): GSPE administered for the first 3 weeks and continued with Thyroxine for another 3 week. Group 4 (GSPE treated): Thyroxine administeredfor 3 weeks, followed by GPSE as in group 3. Group 5 (Spirulina Protected); Spirulina and Thyroxine administration as in group 3. Group 6 (Spirulina treated): Spirulina andThyroxineadministration in group IV.The Hypothyroidism experiment (B) rats divided also into 6 groups similar the above design in Hyperthyroidism experiment (A) but carbimazole dose is stable (1.8mg/kg b.wt) in the 3 weeks.In Hyperthyroidism Spirulina and GPSE increase serum total cholesterol, triacylglycerols with down regulation of liver Caspase-8 and significant upregulation of Bcl2 gene. In HypothyroidismSpirulina and GPSE exhibited down regulation in liver miRNA 224, PKCα with significant upregulation of miRNA 382gene in Hypothyroid rats.Spirulina and grape seed may treat and prevent hyperthyroidism or Hypothroidsim in rats, according to a new study.