Deltamethrin (DM) is a synthetic insecticide that is commonly used in agriculture and veterinary medicine. Furthermore, animal and human studies have shown that DM has a negative impact on the liver. This study was carried out to evaluate the protective effect of Coenzyme Q10 (CoQ10) supplementation against DM hepatotoxicity in broiler chickens. Sixty chicks were divided into 4 groups. First group (basal diet), second group (40 mg CoQ10 /kg diet), third group (300 mg DM/kg diet), and the fourth group (300 mg DM /kg diet) and (40 CoQ10mg/kg diet). The treatment was administered to the final three groups for 35 days. DM declined body weight (BW), body weight gain (BWG), and increased feed conversion rate (FCR). Significant increases in aspartate aminotransferase (AST), alanine aminotransferase (ALT), malondialdehyde (MDA), with a significant drop in levels of reduced glutathione (GSH) and superoxide dismutase (SOD) were also recorded in this group. Caspase-3 and B cell lymphoma 2 (BCl2) were substantially upregulated by DM in liver tissues. In addition, alterations in histopathology as severe congestion and mononuclear inflammatory cellular infiltration of the hepatic parenchyma with vacuolation of the hepatic cells were recorded in the examined liver of chickens intoxicated with DM. Concurrent CoQ10 supplementation with DM resulted in a significant improvement in estimated parameters when compared to the DM group. Because of its protective effects against DM-induced hepatotoxicity in broilers, dietary CoQ10 is recommended.