Albendazole is an abroad spectrum anthelmintic used for treatment of different parasites.Liver toxicity and elevation of liver marker enzymes occur secondary to usage of albendazole(alb) .Organium majorana extract (OME) has a hepatoprotective effect against albendazole (alb) enhanced hepatic toxicity in rats as assayed in the present study.Twenty male rats were divided into four equal groups five rats for each group .Group1: (Normal control), received no drugs, Group 2: (OM-treated), rats received an oral dose of OME (200mg/kg b.wt/day) for 30 successive days .Group 3: (alb treated ) received an oral dose of alb (7.5 mg/kg b.wt.) for 15 successive days .Group 4 (OME protected+ alb ), rats pretreated with OME (200 mg/kg b.wt/day) orally for 30 days before alb treatment for 15 days.Results showed significant (P<0.05) raise in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) ,total protein ,direct bilirubin and decrease of albumin level compared to control group and group treated with OME. Albendazole also induced histopathological alteration in liver tissue. OME showed significant protection against albendazole-induced hepatotoxicity that confirmed through serum biochemical analysis and the histopathological examination of liver tissues and might be beneficial for the hepatotoxicity.