This study was undertaken to identify Eimeria species in Japanese quail (Coturnix coturnix japonica) from different localities in Kalioubia governorate. In addition, studing the efficacy of some natural anticoccidial products (Propolis and Neem; Azadirachta indica) compared to Amprol (amprolium hydrochlorid.plus ethopobate) as chemical anti coccidial drug on the oocyst output, pathogenicity (weight gain, feed conversion ratio, mortality, severity of diarrhea, and intestinal lesion scores and oocysts sporulation. Out of 900 examined quails, 575 (63.8%) were infected by Eimeria. Quail farms in Abozabl showed the highest infection (73.3%), while the lowest infection (58.6%) was recorded in quail farm in Kafrshokr. The detected species were E. bateri, E.uzura, E. tsunodai, , Eimeria bahli and Eimeria colini. On the basis of the study results, it was concluded that Amprol showed better results in term of reduction of oocyst count and reduction of sporulation%, followed by Propolis and Neem. All the used drug had a good effect on weight gain, feed consumption. In addition, decreasing the coccidial pathogenicity and mortalities.