The present study aimed to investigate the epidemiology of mange disease in Menofia governorate and to identify the efficacy of different acaricides to control mange mites infesting sheep and goat in the governorate. For this purpose, a total number of 1500 sheep and 750 goats were examined during the different months and seasons of the year by visual inspection of animals' body. The examined animals were also parasitologically and microscopically examined. All parasitological positive samples were subjected to different treatment protocols with acaricides. The results revealed that prevalence of mange in sheep was 24.5% and 23.33% in goat and the highest prevalence of mange in sheep and goat was in summer season, (36.57%) in sheep and (32%) in goat, while the lowest prevalence was in winter, (14%) in sheep and (14.8%) in goat. Moreover, the highest prevalence of mange was observed in Shebein El-Kom , (6.73% , 5.73% ), in sheep and goat, respectively, while the lowest prevalence was noticed in El-Bagour (4% , 3.73%), in sheep and goat, respectively. On the other hand, the results revealed that the efficacy of deltamethrine was 63.55%, the diazinon efficacy was 81.2%, the ivermectin efficacy was 81.95%, On the other hand, the treatment protocol of infested animals with deltamethrine + ivermectin proved an efficacy of 87.63% and the efficacy of the treatment protocol with diazinon + ivermectin was 94.7%.