The present study was performed on 250 random samples of fresh meat and meat products viz: Beef burger, kofta; minced meat and sausage (50 for each), were collected from different shops (25gm from each sample) at Kaliobia Governorate, Egypt, for detection the prevalence of some toxigenic food-borne bacteria , beside the phenotypic characterization and detection of some virulence genes . Bacteriological examination of the collected samples resulted in, isolation of 90 (36.0%) isolates of S. aureus isolates (41/16.4%); E. coli (25 /10.0%); B. cereus (21/8.4%) and Salmonella (3/1.2%) were recovered from 250 samples. ,Seven serogroups (O55:H7; O111:H4; O125:H18; O126:H7; O128:H27; O142:H2and O158:H2) were detected in 25 isolated E. coli strains. The antibiotic sensitivity tests for the isolated strains show multiple antibiotic resistances (ampicillin; methicillin; oxytetracycline; amoxicillin; streptomycin; erythromycin; doxycycline and cefotaxime). Therefore, E. coli; S. aureus and B. cereus strains especially antibiotic resistances ones are meat-borne pathogens of public health important.