The present study was designed to define  the effects of daily administration of 100 mg vitamin E\kg on side effects in mice treated with dexibuprofen (7.2 mg/kg, P.O once daily) for 21 consecutive days and its antioxidant scavenging capacity. Blood samples were collected from mice on 1^st, 2^nd, 14^th, 21^st days post –treatment and tissue samples were collected on 7^th, 14^th days post-treatment to assess the protective effects of vitamin E. The results indicated  significant increase in antioxidant enzymes Glutathione peroxidase, dismutase superoxide dismutase(SOD)&catalase (CAT) together  decrease the level of malondialdehyde  besides  diminished and in portal fibrosis  and decrease in congestion of hepatic blood vessels and sinusoids caused by dexibuprofen administration as demonstrated by kidney histopathology Therefore, Vitamin E should be taken with dexibuprofen to decrease its side effects.