In this research, we evaluated the effect of meloxicam, (NSAID) on antioxidant parameters and lipid peroxidation and liver, kidney histopathology in rats after oral administration for 21 days This study was conducted to evaluate the protective effects of vitamin E (100 mg/kg) on meloxicam possible adverse effects (0.27 mg/kg) for 21 consecutive days and its antioxidant scavenging capacity. Blood samples were collected at 1^st ,7^th, 14^th, 21^st days post-treatment and liver and kidney samples were collected at 7^th,14^th days post treatment to assess  the protective effects of Vit. E. Our results indicated a significant increase in antioxidant enzymes CAT, SOD, GPX and a significant decrease in MDA. Also, a decrease in fatty changes of liver and a decrease in degenerative changes In hepatocytes caused by meloxicam administration, as demonstrated by hepatic histopathology. Also, showing a decrease in degenerative changes in renal tubular epithelium caused by meloxicam administration, as demonstrated by kidney histopathology