Cadmium (Cd) is a well-known hazardous environmental contaminant. Non-steroidal anti-inflammatory drugs (NSAIDs) have been reported to have a deleterious effect on liver and kidney. Therefore, in this study, we investigated whether NSAIDS could potentiate the toxic effect of Cd on liver and kidney. Twenty male Wister rats were divided randomly into 4 groups. Group 1:the control was injected saline daily. Group 2: received cadmium (5mg/kg) daily. Group 3: served as piroxicam were injected a single dose (10 mg/kg, i.p.). Group 4: received both Cd+Px. After 14 days, all rats were euthanized and blood samples, stomach, liver, and kidney tissues were collected. Treatment with Cd or Px alone significantly increased the liver and kidney function markers. However, when Cd and Px were given in a combination, Px potentiated the Cd-induced cellular damage in liver and kidney when compared to their individual treatment in liver and kidney functions and histopathological examination. Their combination could also enhance the apoptosis.