Lipopolysaccharides (LPSs) are strong hepatotoxin that is used to induce oxidative liver damage in the experimental animal model. This study aimed to investigate how the antioxidant properties of garlic are able to protect against LPSs-induced hepatic damage in mice. Forty male albino mice were divided into 4 equal groups; Control, Garlic, LPS and garlic protected group. LPSs was administered at a dose of 3 mg/kg b.wt once intraperitoneally and garlic was given intragastric at a dose of 500 mg /kg body weight dissolved in distilled water once daily for three weeks. LPSs induced a significant liver injury manifested by significant increased serum ALT and AST activities and total bilirubin concentration accompanied by significant decreased serum albumin and total proteins levels. Also, LPSs induced a significant increase in the level of hepatic malondialdehyde (MDA). Moreover, it induced a depletion in the antioxidant status manifested by reduction of hepatic glutathion (GSH), glutathion peroxidase (Gpx) and super oxide dismutase (SOD) in the liver homogenate. LPSs induced a microcytic hypochromic anemia with significant decrease in total leukocytic and lymphocytic count. The examined hepatic tissue revealed karyomegalocytes with ballooning degeneration and fibrosis in portal area. On the other hand, garlic alleviated the liver damage caused by LPSs. It was concluded that the anti-oxidant properties of garlic powder are effective in reversing the LPSs oxidant hepatic damage in mice.