72780

Spirulina platensis and alpha lipoic acid are protective against the deleterious effects of aspartame on the liver and kidneys of rabbits

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

Biochemistry

Abstract

Spirulina platensis and alpha lipoic acid are the most important antioxidants. The purpose of this study was to explore the adverse effect of artificial sweetener (Aspartame) and the protective role of alpha lipoic acid and spirulina in alleviating the deleterious effects of aspartame on the liver and rabbit kidneys.Forty two Rabbits were classified into seven equal groups.Group I: (Control group) received no drugs. Group II: rabbits administered with alpha-lipoic acid (100mg/kg b.wt/day). Group III: rabbits received spirulina platensis (1500 mg/kg b. wt/day). Group IV: rabbits received aspartame (250 mg/kg. b.wt/day). Group V:rabbits received aspartame (250 mg mg/kg b. wt) and treated with alpha- lipoic acid (100 mg/kg b. wt). Group VI: rabbits received aspartame (250 mg mg/kg b.wt) and treated with spirulina. Group VII: rabbits received aspartame and treated daily with alpha- lipoic acid and spirulina for 8 weeks.Blood samples for serum separation were collected once from all animal groups aftereight weeks ofexperiment. The results revealed a significant increase in serum liver marker enzymes (ALT), (AST), (ALP)},kidny function tests (urea, creatinine, uric acid) and lipid profile (total cholesterol and triacylglycerols) and total protein concentration with a significant reduction in serum albumin in aspartame- administrated group.Coadministration of spirulina and alpha lipoic acid with aspartame treated rabbits ameliorate aspartame dangerous effects as revealed by a significant enhancement in all previous biochemical parameters to its normal ranges.

DOI

10.21608/bvmj.2019.16355.1085

Keywords

Aspartame, Spirulina platensis, alpha-lipoic acid, Hepatorenal function, Rabbits

Authors

First Name

Hamam

Last Name

Attiya

MiddleName

-

Affiliation

1 Department of Biochemistry, Faculty of Vet. Med., Benha University, Egypt.

Email

hamamattiya@yahoo.com

City

elmonofia

Orcid

-

First Name

Samy

Last Name

Hussein

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Vet. Med., Benha University, Egypt.

Email

samyhussein@yahoo.com

City

-

Orcid

-

First Name

Yakout

Last Name

AlSenosy

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Vet. Med., Benha University, Egypt

Email

yakoutalsenosy@yahoo.com

City

Egypt

Orcid

-

First Name

Mahamoud

Last Name

Arafa

MiddleName

-

Affiliation

Department of Biochemistry and food deficiency, Animal Health Research Institute, Agriculture Research Center, Dokki, Giza, Egypt.

Email

mahamoudarafa@yahoo.com

City

-

Orcid

-

Volume

36

Article Issue

2

Related Issue

5670

Issue Date

2019-06-01

Receive Date

2019-08-28

Publish Date

2019-06-01

Page Start

274

Page End

281

Print ISSN

1110-6581

Online ISSN

2974-4806

Link

https://bvmj.journals.ekb.eg/article_72780.html

Detail API

https://bvmj.journals.ekb.eg/service?article_code=72780

Order

28

Type

Original Article

Type Code

812

Publication Type

Journal

Publication Title

Benha Veterinary Medical Journal

Publication Link

https://bvmj.journals.ekb.eg/

MainTitle

Spirulina platensis and alpha lipoic acid are protective against the deleterious effects of aspartame on the liver and kidneys of rabbits

Details

Type

Article

Created At

22 Jan 2023