Foot-and-mouth disease (FMD) is a highly contagious and economically devastating viral disease of
cloven-hoofed animals. In Egypt, the local commercial (trivalent O Panasia-2/A Iran-05/ SAT2/EGYA-
2012) and imported (trivalent O Manisa /A Iran-05/ SAT2/EGY-A-2012) inactivated vaccines were
used for rapid control of the disease. We aimed to determine the cross protection between FMD virus
serotypes O and A local Egyptian isolate with vaccinal strains in the local commercial and imported
vaccines using challenge experiment. By the 7th day post challenge with either O/EGY-4-2012 or
A/EGY/1/2012 isolates, the vaccinated cattle with either local commercial or imported vaccine were
clinically protected by 100% with local commercial vaccine and 80% with imported vaccine for O/EGY-
4-2012. The protection values were 100% and 80% with cattle challenged with A/EGY/1/2012 and
vaccinated with a local commercial or imported vaccine respectively. In conclusion, FMD virus
Egyptian isolates O and A was antigenically similar to that of vaccinal strains in local commercial and
imported vaccines which provide good protection