A total of 75 one-day old chicks (Cobb local breed) At the 1 day old the chicks were randomly divided
into 3 equal separate groups; 25 chicks each. Group 1 fed on prebiotic beta glucan 200gram/ton, group
2 fed on probiotic saccharomyces servicee 500gram/ton and group 3 control fed on balanced commercial
ration. The result revealed that the group of broiler fed on prebiotic increase the lysozyme more than the
group of broiler fed on probiotic and after artificial infection, the group treated with prebiotic was able
to face the clostridial infection more than group treated with probiotic. The histopathological
examination showed that increase length and width of intestinal villi of chicken treated with prebiotic
more than that of probiotic