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31855

Correlation between foot-and-mouth disease virus antigenic mass, titer and immune response in vaccinated sheep

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Last updated: 04 Jan 2025

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Abstract

The antigen mass load of foot-and-mouth disease virus (FMDV) is one of the critical clues to produce a
potent vaccine. In the current work, the quantification of the virus 146S antigen content was described
and the relationship between antigen mass in the vaccine and the immune response to FMDV in
vaccinated sheep were investigated. It was found that FMD vaccine containing at least 1.5 μg/2ml (small
ruminant dose) or 3 μg/2ml (cattle and buffaloes dose) from each serotype of FMDV 146S particles and
virus titers 6.55-7.3 log10 TCID50/ml gave protective immune response against FMDV. Moreover,
relying on the antigenic mass coupled to ultrafiltration of the virus was showed to be of better quality
and potency than depending on the volume of the virus suspensions in the formulation of FMD vaccine;
however, the former technology needs with standing more cost and effort

DOI

10.21608/bvmj.2015.31855

Keywords

Foot-and-Mouth disease virus, 146S, antigen mass, Ultrafiltration

Authors

First Name

Hany

Last Name

Abu-Elnaga

MiddleName

-

Affiliation

Department of Foot and Mouth Disease, Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, Egypt

Email

h.abu-elnaga@hotmail.com

City

-

Orcid

-

First Name

Hossam

Last Name

Fawzy

MiddleName

-

Affiliation

Department of Foot and Mouth Disease, Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Ekbal

Last Name

Farouk

MiddleName

-

Affiliation

Department of Foot and Mouth Disease, Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Ehab

Last Name

Ibrahim

MiddleName

-

Affiliation

Department of Foot and Mouth Disease, Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Gamil

MiddleName

-

Affiliation

Department of Foot and Mouth Disease, Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Said

Last Name

Zidan

MiddleName

-

Affiliation

Department of Foot and Mouth Disease, Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, Egypt

Email

-

City

-

Orcid

-

Volume

28

Article Issue

2

Related Issue

5413

Issue Date

2015-06-01

Receive Date

2019-05-16

Publish Date

2015-06-01

Page Start

12

Page End

19

Print ISSN

1110-6581

Article File

BVMJ_Volume 28_Issue 2_Pages 12-19.pdf

PDF . 806.7kB

Link

https://bvmj.journals.ekb.eg/article_31855.html

Detail API

https://bvmj.journals.ekb.eg/service?article_code=31855

Order

2

Type

Original Article

Type Code

812

Publication Type

Journal

Publication Title

Benha Veterinary Medical Journal

Publication Link

https://bvmj.journals.ekb.eg/

MainTitle

Correlation between foot-and-mouth disease virus antigenic mass, titer and immune response in vaccinated sheep

Details

Type

Article

Created At

22 Jan 2023