The present study was to evaluate anti-leukopenia and antioxidant effects of Moringa peregrina seeds
oil at dose of 381 mg/kg in 400mg/kg.b.w Benzene and/or 20 mg/kg.b.w 5-Flourourasil induced
leukopenia rats 2 weeks after induction of leukopenia in rats, Moringa peregrina seeds oil at dose of 381
mg/kg was administrated for 30 consecutive days. On the 31th day, the rats were sacrificed for the
estimation of Hemoglobin (Hb%), Total Leucocyte Count (WBC) and Platelet Count (PLT) as well as
biochemical parameters; Alanine Transaminase (ALT), Aspartate Transaminase (AST), Alkaline
Phosphatase (ALP), Albumin(Alb) , Total Protein, Lactate Dehydrogenase (LDH), Creatine Kinase
(C.K), Urea , Creatinine ,Reduced Glutathione (GSH), Superoxide Dismutase (SOD), Catalase (CAT),
Total Cholesterol (T.Ch), Triglycerides (TG), P53 Gene Expression, Nitric Oxide (NO) , Thiobarbituric
Acid Reactive Substances (TBARs) and Tumor Necroses Factor-α (TNF-α). The results of this study
also showed that administration of Moringa peregrina seeds oil at dose of 381 mg/kg.b.w to leukopenia
induced rats demonstrated a significant (P<0.01) increase in Hb%, WBCs and PLT as well as a
significant (P<0.01) improvement in biochemical parameters and life span as compared to the benzene
and /or 5-Flourourasil control rats. The histological examinations of this study revealed lung damage
and degeneration in the lung of benzene and /or 5-Flourourasil treated rats. Also, lung of Moringa
peregrina seeds oil at 381mg/kg rats showed significant improvement and protection against benzene
and /or 5-Flourourasil harmful effect. On the other hand, the results clearly suggest that the oxidative
stress of benzene higher than 5-Flourourasil