Pneumonia in Boer goats is a multifactorial disease required a special care for economic, effictive and
rapid treatment. Therefore, this study aimed to compare the therapeutic efficacy of three antibiotics
(Tulathromycin, Florfenicol and Amoxicillin) in treatment of klebsiella pneumoniae in Boer goat. Forty
five pneumonic Boer goats suffered from respiratory distress that were divided into three groups (each
of 15) according to the type of the antibiotic used (Tulathromycin, Florfenicol and Amoxicillin). All
Boer goats were examined before treatment (0 day) and on the 1^st, 3^rd, 5^th and 7^th days post treatment.
The results revealed a clinical recovery of 80%, 73.3% and 60% of cases after first dose of
tulathromycin, florfenicol and amoxicillin, respectively. The results of hematological, serum
biochemicals and pulmonary function tests revealed improvement of most of parameters from the 3rd
day of treatment by tulathromycin and florfenicol. However, treatment by amoxicillin restored the
parameters from the 5^th day and might be extended to the 7^th day of treatment. Isolates were subcultured
and confirmed as K. pneumoniae using standard microbiology techniques. The results were confirmed
by the result of antibiotic sensitivity test against klebsiella which was highly sensitive to tulathromycin,
sensitive to florfenicol and moderately sensitive to amoxicillin. We concluded that tulathromycin has a
better efficacy than florfenicol and amoxicillin in treatment of Boer goats affected with k. pneumoniae