This study designed to investigate the anti –inflammatory effect of zinc oxide nanoparticles (ZnONPs)
and \ or aloe component (aloin) on inflammatory mediators and oxidative stress in dextran sulfate
sodium salt induced ulcerative colitis(UC) in rats. sixty-four albino rats divided into eight equal of eight
rats each. Group 1:(normal control) received no drugs , group 2:( ulcerative colitis) rats received dextran
sulfate sodium salt 3% in drinking water, group 3:( ZnONPs) rats administered ZnONPs (5mg/kg body
weight) orally for 3weeks, group 4: (aloin ) rats administered orally with 1ml of aloin 0.1% daily for
3weeks, group 5: (aloin + ZnONPs) rats orally administered with NZnO (5mg/kg body weight) and
(aloin 0.1%), daily for 3weeks, group 6: (ZnONPs +UC) rats with ulcerative colitis orally treated with
ZnONPs (5mg/kg body weight) daily for 3 weeks, group7: (aloin+UC) rats with ulcerative colitis orally
treated with (aloin 0.1%), daily for 3weeks, group 8: (aloin+ ZnONPs +UC) rats with ulcerative colitis
orally treated daily with ZnONPs (5mg/kg body weight)+aloin (1ml aloin 0.1%) for 3weeks. The
obtained results revealed that, administration of ZnONPs and\or aloin to rats with ulcerative colitis
significantly reduced elevated serum total cholesterol and TG concentrations, and markedly increased
the reduced HDL-C level. On the other hand, elevated level of COX-2, IL-6, MDA and TNF-α in UC
rats were significantly reduced, with significant increase of the reduced level of GSH. Results suggest
that ZnONPs modulates UC, while aloin showed high efficacy to normalize UC tissues and may
considered as potential treatment for UC and other inflammatory bowel disease.