Several investigations on crisis management are demonstrating interest in the role of occupational safety culture awareness factors. Thus, focusing on safety culture factors is an essential issue in health and safety as a means of the mitigating crisis caused by nature in the workplace. This study investigates the influence of hotel safety culture on employees' safe-behavior during the crisis of Covid-19 in order to recommend some practices and allowing those who in charge of this industry to follow during this period to overcome this crisis. Therefore, the first step is to identify the relevant safety culture factors. A measurement tool in the form of a questionnaire was used to explore the impact of hotel safety culture (HSC) on employee safe-behavior. The questionnaire survey contains twelve constructs, namely: “risk management; safety training; safety knowledge; safety rules; safety perceptions; safety supervision; safety commitment; safety rewards and punishment; safety environment; safety communication; safety compliance and safety participation". Confirmatory factor analysis (CFA) was utilized to analyze 257 questionnaire forms collected from employees. The study results depict six safety culture factors out of ten proposed (risk management; safety training; safety rules; safety supervision; safety environment; safety communication) were the most important factors affecting employees' safe-behavior during the crisis of COVID-19.