The study dealt with the antifungal activity of some plant extracts against the fungi of mold rot of the roots that infect the roots of the cantaloupe plant, where the affected cantaloupe plant roots were collected from different places in Egypt, including (Nubaria _ Khattaba ‌‌_ Medina Sadat _ Egypt's Desert Road, Desert Road kilo 76) and the Fusarium Solani fungi _ and fungi were isolated. Lithium - Solanese Resect Fungus, seven wild plants were collected, then plant extracts were made using an organic solvent (methanol) and the results of an anti-fungal activity experiment showed that all the plant extracts led to a significant inhibition of the growth of the tested fungi. Inhibition against Fusarium solani fungi 52.6 mm and against fungicide solani fecunda 22.2 mm and proven studies of Walter Keba minute the effect of plant extract of the taxa on the cellular composition of Fusarium solani fungi studies showed an increase in the thickness of the fungal cell wall. Chemical analysis of the extract of the tax collector using the HPLC device. The plant extract of the tax collector contains phenolic and flavonoids, which are important materials to inhibit the growth of fungi.