Ehrlich Ascites Carcinoma (EAC) is an experimental transplantable neoplasm, which discovered firstly as a mammary tumor in mouse. Like other cancers growing in body cavities, EAC cells fill the mouse peritoneum by rapid cells division causing a local inflammatory reaction, with increasing vascular permeability leading to intense edema formation, cellular migration and progressive ascitic fluid formation.Cisplatin (Cis) is one of the most frequently used antineoplastic agents for various types of cancer. Cisplatin exhibited its antitumor effect via generating DNA adducts, which in turn leads to cell cycle arrest and initiating apoptotic signaling pathway. Unfortunately, the use of Cis in cancer patients is now strictly regulated due to the fact that it is linked to a variety of adverse effects, including nephrotoxicity, severe nausea and vomiting, myelosuppression, ototoxicity, and neurotoxicity. Furthermore, many cisplatin-treated patients who relapsed after a period of recovery have developed drug resistance. Natural products have played an essential role in health promotion and illness prevention for many years. There is a lot of data that is linked to the creation of natural product-based medicines that have been utilized to inhibit, reverse, or slow down the carcinogenesis process. Hesperidin (Hesp) is a bioflavonoid found primarily in citrus fruits such as clementine, lemons, mandarins, grapefruit, and oranges. Hesperidin is proposed to provide a wide range of health benefits including anti-inflammatory and antimicrobial properties, as well as cancer treatment.