The efficacy of maduramycin (Cygro® 10G, recommended dose; 5 mg/kg of feed) as anticoccidial dietary supplementation in broiler chickens infected with coccidial oocysts on hematological profile, serum biochemical parameters and the performance parameters (body weight gain, food intake, food conversion as well as mortality), was studied. A total of 40 one‐day‐old broiler chicks (body weight: 42.15±0.27gm) were randomly divided into two treatment groups: (a) Infected group without supplementation and (b) Infected group supplemented with Cygro® 10G. Dietary Cygro® 10G supplementation significantly improved weight gain (WG), feed conversion ratio (FCR) and mortality compared to non-supplemented control treatment. WBCs, RBCs, PCV, Hb, MCV, MCH and LYM were showed a significant increase in supplemented group that fed on maduramycin compared to non-supplemented control group. We concluded from the obtained results that maduramicin can improve the feed conversion ratio, reduce feeding cost, and shorten the feeding period.