Colibacillosis is the main trouble confronted in cattle outputting, causing considerable economic losses. The infected or carrier calves and cows shed the bacteria in the feces and causing the transmission of pathogenic E. coli to calves at the environment. Diagnosis of E. coli infection in calves relies on history, clinical signs, the culture of bacteria, and serotyping of bacteria. Colibacillosis requires immediate response to colibacillosis is variable, centered on isolation and treatment of dehydration &antimicrobial therapy. Parental antibiotics can give a good result if given in the early stage, but not without rehydration therapy. The prevalence of colibacillosis differs from 5.4 to 100%, and it is roughly estimated that calf mortality connected with colibacillosis of 20% may reduce net profit to 40%. The emergence of multi-drug resistant E. coli isolated from diarrhetic calves has been raised as a new concern for public health and food safety authorities. Routine monitoring of E.coli isolated from diarrhetic calves will help reduce the transmission to humans and help select the most effective antibiotics. In conclusion, dam vaccination before calving, improve hygiene around calving and proper colostrum administration considered the main factors to control and prevent the disease. In addition, vigilant monitoring of E. coli isolates recovered from diarrhetic calves for antimicrobial sensitivity pattern will help choose the appropriate antibiotic and decrease the transmission of theses isolates to humans.