Clostridium perfringens toxins are the main cause of lesions and symptoms associated with diseases caused by its infection. There are two main groups of toxins; major and minor. The major toxins are alpha (CPA), beta (CPB), epsilon (ETX), and iota (ITX) toxins. Theses toxins are lethal and necrotizing agents. minor toxins such as eta, theta (θ), kappa, lambda, mu, nu toxins, neuraminidase, sialidase, enterotoxin, non-alpha-delta-theta hemolysin, and metabolic active substance. Recently there are newly discovered toxins Such as enterotoxin and a cytotoxic beta -2 toxin. Theses toxins may play an important role in pathogenesis of the diseases and need more investigation. Here we summarized important data about Clostridium perfringens toxins.