Introduction: Mandible fractures account for a significant portion of maxillofacial injuries and the evaluation, diagnosis, and management of these fractures remain challenging despite improved imaging technology and fixation techniques. Platelet-rich fibrin (PRF) has come up as the second-generation platelet concentrate, and its production protocol attempts to accumulate platelets and release cytokines in a fibrin clot, which showed increased levels of growth factors that influence bony regeneration.
Aim of the study: Evaluation of the effects of PRF in bone regeneration and healing in cases of fracture mandible.
Material and methods: Comparative study included 40 patients divided into 2 equal groups. The first group (the study group), mandibular fractures were treated with reduction and fixation with plates and screws along with PRF membrane at fracture line. The second group, mandibular fractures were treated with reduction and fixation with plates and screws only. Radiological follow up was done by the means of computed tomography to measure mean bone density for fracture line at 1week, 3 months, 6 months post operatively as an indicator for bone healing.
Results: Faster bone regeneration was observed in the study group. The mean bone density was for study group at 1week, 3 months and 6 months 270.80±79.60, 575.40±83.49 and 890.10±130.55 respectively, in contrast to control group where the mean bone density was 223.00±53.53, 408.80±76.59 and 635.80±94.58 for 1 week, 3months and 6 months respectively.
Conclusions: PRF could be considered as an adjuvant to accelerate bone healing in mandibular fractures and valid option in regenerative therapies in maxillofacial surgeries.