Background: Diabetic retinopathy (DR) is one of the leading causes of visual impairment and blindness in patients aged 20-47. Clinically, DR has two stages: non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). The aim of this work was to assess retinal microvasculature abnormalities in different stages of non-proliferative diabetic retinopathy using optical coherence tomography angiography.
Methods: This cross-sectional case control study was carried out on 90 eyes of 55 subjects attending outpatient clinic of Ophthalmology department (35 of healthy non-diabetic, 15 of mild NPDR, 27 of moderate NPDR and 13 of severe NPDR).
Results: At 3x3 size scan of OCTA, FAZ and PERIM were significantly more enlarged in case group compared to the control group (both p < 0.001) however, superficial and deep VD% were significantly lower in case group compared to the control group (both p < 0.001). There was a significant difference among the three subgroups (mild, moderate and severe) as regards FAZ, superficial and deep VD% (all p < /p>