Background: Methacrylate is a sterile white powder composed of organic polymers. Once poured into a wound, the particles absorb exudate from the wound site, then hydrate and aggregate to form an irreversible film dressing. The aim of this study is to evaluate the effect methacrylate powder in healing of chronic non-healing pressure sores, burns "partial thickness burns 2nd degree burn", venous ulcers and acute traumatic wounds in terms of shortening duration of healing, ease of use, serous exudates, and less pain. Patients and methods: 30 patients with a clinical diagnosis of 2nd, 3rd degree burn, venous ulcers, pressure sores and post traumatic were enrolled in this study. Patients underwent dressing with methyl acrylate powder every 7-10 days according to soaking of the dressing. Results: 20 (66.6%) cases completely healed with normal epithelium, 7 (23.3%) cases did not respond and needed graft and 3 (10%) cases complicated with reopening and need graft. Number of dressings ranged from 2 to 5 resulting in an average of 3. Duration of healing ranged from 2weeks to5 weeks, resulting in average of 3 weeks. Conclusion: Methylacrylate powder dressing offers a helpful solution in healing of different types of burn, pressure sores, post traumatic patient with raw areas with minimal pain due to less numbers of dressings, but multiple dressings increasing cost.