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The Diagnostic and Prognostic Significance of ARID1A and CD8+ Expression in Endometrial Hyperplasia and Endometrial Endometrioid Adenocarcinoma (Immunohistochemical study)

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Last updated: 22 Jan 2023

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Abstract

Background: Epigenetic driver mutations and tumor microenvironment could play an important and promising role in diagnosis, prognosis, and prediction of different endometrial lesions.
Aim: To determine their putative diagnostic and prognostic value, this work analyzes the immunohistochemical (IHC) expression of ARID1A and CD8+ in endometrial hyperplasia (EH) and endometrioid endometrial adenocarcinoma (EEA).
Material and methods: The 80 distinct endometrial lesions included in this retrospective study included (20) EH without atypia, (30) atypical EH (AEH), and (30) EEA. Clinicopathological characteristics and survival of examined cases were correlated with the IHC expression of ARID1A and CD8+.
Results: ARID1A negative expression was significantly associated with EEA (46.7%) and AEH (30%), while its positivity was associated with EH without atypia cases (100%) (P

DOI

10.21608/bmfj.2022.156719.1642

Keywords

ARID1A, CD8+, Endometrial hyperplasia, Endometrioid adenocarcinoma

Authors

First Name

Rasha

Last Name

El Sawi

MiddleName

Mohammed

Affiliation

Department of Pathology, Faculty of Medicine, Benha University, Egypt

Email

rashaelsawi@hotmail.com

City

-

Orcid

-

First Name

Amany

Last Name

Hassan

MiddleName

-

Affiliation

Department of Pathology, Faculty of Medicine, Mansoura University, Mansura, Egypt

Email

dramanyhassan@mans.edu.eg

City

-

Orcid

-

First Name

Samia

Last Name

Youssef

MiddleName

Ahmed

Affiliation

Department of Pathology, Faculty of Medicine, Benha University, Egypt

Email

dr_samiayoussef@hotmail.com

City

-

Orcid

-

First Name

Hala

Last Name

Agina

MiddleName

Adel

Affiliation

Department of pathology, Faculty of Medicine, Benha university, Egypt

Email

halaagina@gmail.com

City

-

Orcid

-

First Name

Hanan

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Pathology, Faculty of Medicine, Benha University, Egypt

Email

hanan_abdelaziz20002000@yahoo.com

City

-

Orcid

-

First Name

Enas

Last Name

Ibrahim

MiddleName

-

Affiliation

Department of Pathology, Faculty of medicine, Benha university, Egypt

Email

dr_enas_ibrahim@yahoo.com

City

-

Orcid

-

Volume

39

Article Issue

Special issue (Academic)

Related Issue

36503

Issue Date

2022-09-01

Receive Date

2022-08-17

Publish Date

2022-09-01

Page Start

294

Page End

318

Print ISSN

1110-208X

Online ISSN

2357-0016

Article File

BMFJ_Volume 39_Issue Special issue (Academic)_Pages 294-318.pdf

PDF . 1.5MB

Link

https://bmfj.journals.ekb.eg/article_259028.html

Detail API

https://bmfj.journals.ekb.eg/service?article_code=259028

Order

301

Type

Original Article

Type Code

787

Publication Type

Journal

Publication Title

Benha Medical Journal

Publication Link

https://bmfj.journals.ekb.eg/

MainTitle

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Article

Created At

22 Jan 2023