Background:Colorectal carcinoma (CRC) is the third most common cancer in the world. The chemokine CXCL9 is a small molecule belongs to (CXC family) which secreted by (IFN-γ) stimulated macrophages. VEGF-α plays central role in the regulation of angiogenesis and lymphangiogenesis.
Aim : This work aimed to evaluate the role of CXCL9 and VEGF α in colorectal adenocarcinoma.

Material and method: This retrospective study was carried upon 50 cases of colorectal adenocarcinoma. CXCL9 and VEGFα immunostaining was done and assessed for each case.

Results: There was an insignificant statistical correlation between both CXCL9 and VEGF -α expression and patient`s age, sex, tumor size and site (P value >0.05). But there was a highly significant inverse statistical correlation between CXCL9 expression and tumor grade, depth of tumor invasion, lymph node metastasis, distant metastasis lymphovascular invasion and tumor stage (P value