Background: Infection with the hepatitis C virus is a public health problem due to its prevalence, morbidity and mortality. Inspite high rate of SVR to treatment by DAAS, still failure to respond to treatment is a problem facing and delaying the achievement of HCV eradication. Identifying predictors of HCV treatment failure prior to the initiation of therapy is important in recognizing high-risk patients and alerting clinicians as to whether they should further intervene to address potential barriers. Methods: This retrospective cohort study was carried out from April 2016 to October 2018. The present study was conducted on 300 cases, 150 received SOF-DAC and 150 cases received SOF-DAC-RBV according to guidelines provided by Egyptian National HCV Control Program guidelines. Results: It was found that among all studied cases, non-response was significantly associated with older age, higher BMI and male gender (p < 0.001,