Objective: the ability of SUPAR (soluble urokinase plasminogen activator receptor) to evaluate sepsis and predict mortality in critically ill children in pediatric intensive care unit (PICU). Methods: the study included 70 critically ill children admitted to PICU , divided into two groups group (A)(critically ill children with sepsis)& group (B) (critically ill children without sepsis(SIRS)) compared to matched age ,sex 30 healthy children as a control group. Clinical examination was performed ,including calculation of the pediatric Risk of mortality (PRISM) and (q sofa) in first 24 hr of admission. Results: suPAR level was significantly higher among the total patient study group compared to controls (p < 0.001) . suPAR was higher in patients with sepsis Group (A)compared to group (B)(critically ill without sepsis) (p < 0.001) ,SUPAR level has significant positive correlation with mortality risk scores (PRISM) score and(q SOFA) score with p-value(or=120,2 pg/ml with accuracy 92%. Conclusions: suPAR has both a diagnostic and a prognostic value for diagnosis sepsis between critically ill children. It also may be superior to the classic laboratory markers as CRP and TLC also can be considered predictor for mortality or organ damage in critically ill children.