Background: Ischemia of the intestines can be defined as inadequate perfusion through the mesenteric vasculature to meet the demands of downstream organs. The purpose of this study was to highlight the role of Contrast-enhanced CT in assessmentof mesenteric ischemia. Methods: This cross-sectional study included 20 patients present with severe abdominal pain, in addition to a variety of non-specific abdominal complaints including nausea, vomiting, and diarrhea. Patients presented with septic shock secondary to ischemic or necrotic bowel. Results: In this study, 80% of Cases were males and 20% of Cases were Females, The Age ranged from 50 years to 85 years with Mean 69.8 ± 11.68. 90% from the studied group suffering from abdominal pain, 70% from the studied group suffering from Vomiting, 70% from the studied group suffering from Diarrhoea, 20% from the studied group suffering from Bleeding per rectum. According to CT findings; 60% from the studied group suffering from Bowel dilatation, 50% from the studied group suffering from Bowel wall thickness, 50% from the studied group suffering from Intramural gas, 50% from the studied group suffering from Mesenteric fat. Conclusion: the contrast Enhanced CT is the first line imaging modality when mesenteric ischemia is suspected.