Introduction: The histological distinction between squamous cell carcinoma both in-situ and invasive from their benign mimic; irritated seborrheic keratosis is still a difficulty. The aim of this study is to invistigate the diagnostic utility of Insulin-like growth factor II mRNA-binding protein 3 (IMP3), and B-cell lymphoma 2 (BCL2 ) in differentiating forementioned cutaneous tumors.
Materials and Methods: This is a retrospective study to include 50 cases , 25(50%) cases of squamous cell carcinoma (SCC), 10 (20%) cases of squamous cell carcinoma in-situ (SCCIS), and 15 (30%) cases of irradiated seborrheic keratosis (ISK) . The immunohistochemical expression of IMP3and BCL2 was studied .
Results: BCL2 was expressed in 12/15(80%) ISK cases compared to 3/10 (30%) in SCCIS and 4/25 (16%) in invasive SCC cases (p < /p>