Introduction: Hematological changes affecting the red blood cells, white blood cells, platelet function, and the coagulation factors were associated with diabetes mellitus (DM). The neutrophil-to-lymphocyte (N/L) and the platelet-to-lymphocyte (P/L) ratios, were offered as markers of inflammation in cardiac diseases, neoplasms and diabetes-related complications. Patients and Methods: A retrospective, cross sectional study of data from 200 patients with type 2 DM who attended the internal medicine clinic in Benha University Hospital. Clinical data were collected, including; age, sex, duration of DM, body mass index (BMI), micro-vascular and macro-vascular complications of DM. Laboratory data were collected in the form of glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG),complete blood count with calculation of the N/L, and P/L ratios. The selected patients were divided into two groups; group I (good glycemic control, HbA1c ≤ 7 %) and group II (bad glycemic control, HbA1c ˃7). Results: Age was statistically insignificant between the two groups (p value of 0.341). HbA1c, BMI, and FBG were significantly higher in group II. A significant higher total leucocyte, neutrophil, and platelet counts in group II were noticed (p = 0.000). There were a significant higher N/L and P/L ratios in uncontrolled diabetics. Linear regression analysis revealed that age, FBG, neutrophil count, P/L and N/L ratios were significant independent parameters associated with HbA1c. Conclusion: The present study proposed that N/L& P/L ratios may be independently associated with poor blood glucose regulation in patients with type 2 DM. Furthermore, diabetic complications were associated with higher N/L & P/L ratios.