Abstract
Background: Vitamin D is mostly known for its essential role in the musculoskeletal system specially in Calcium and phosphorus metabolism , yet it is recently associated with different neurological disorders.
Objective: To study the relationship between vitamin D level and incidence of diabetic peripheral neuropathy in Diabetes type 2 .
Methods: A case-control study included a 100 participants , 50 type 2 diabetic patients with diabetic peripheral neuropathy and 50 healthy controls. The patients included had clinical assessment and NCS . And all patients and control had assessment of BMI ,fasting and 2-h hpp blood sugar, HbA1C, and vitamin D level.
Results: Serum vitamin D level was significantly lower in patients compared to control (P value = 0.001). For the patients group, females and patients with MNSI score more than 4 had significant lower vitamin D level (P value = 0.001 and 0.001, respectively).
Significant negative correlation was found between vitamin D level and Peroneal nerve latency ( p value 0.048 ), otherwise no correlation between vit D level and results of nerve conduction study.
Significant strong inverse correlation was found between vitamin D level and severity of PDN - MNSI score – ( p value 0.002 ) .
Conclusion: Low Vitamin D was highly prevalent in DPN patients. Females and patients with severer form of neuropathy are more liable for lower vitamin D levels