Background: It is well known that the number of surviving preterm infants is today steadily rising. In spite of the improvements in perinatal medicine, brain injury is still a major clinical problem and remains an important cause of perinatal morbidity and mortality. The main aim to assess the significance of universal cranial ultrasound screening in all preterm neonates in the neonatal ICU with gestational age between 28 and 37 weeks of gestational age even if clinically silent. Methods: 100 preterm neonate were examined by cranial doppler ultrasound at radiology department of Benha Children Hospital (BENCH). 52 of them were male patient and 48 were female. The age ranging from 28 to 37 weeks (early neonate from 28 to 32 weeks and moderate & late neonate from 32 to 37 weeks, using two transducer probes, convex Array transducer (6 MHz) and Linear Array transducer (7.5 MHz). The anterior fontanel was used as the principal acoustic window. Results: Through the scheduled study period, 100 preterm neonates were examined by convex array transducer and linear array transducer, the anterior fontanel was used as the principal acoustic window, 52% of them were male patients and 48% were female patients, with age ranging from 28 to 37 weeks classified as group I > 32 weeks represent 44% and group II ≥ 32 weeks represent 56%. Conclusion: Cranial ultrasound was proven to have a significant role in evaluation neonatal brain problems in preterm patients while most of abnormal brain scans are usually asymptomatic patients.