Background: Imaging of soft tissue tumors requires a multimodality approach. Ultrasound (US) or MRI is chosen according to the clinical characteristics, location of the soft tissue tumor, and patient. The aim of the present study was to establish new diagnostic criteria and improve the diagnostic efficacy of MRI and US with Doppler in assessment of soft-tissue lesions. Patients and methods: This cross-sectional study was conducted at Radiology Department; Benha University during the period from February 2018 to September 2019. Inclusion criteria: Patients who suffer from soft tissue lesions either superficial or deep in both sex and any age group. Ultrasound can detect fine details of small lesions. MR imaging can evaluate tumour staging, neurovascular involvement, tumour necrosis and preoperative planning. Results: The study included 60 patients with soft-tissue lesion (19 females and 41 males), their ages ranged from 5 to 70 years with the mean of age 30.6 ± 15.8. The most common lesion diagnosed among the studied group was   hemangioma (21.66%) and picture of ganglion (13.33%) followed by moderate degree of osteoarthritis (11.66%). Conclusion: Magnetic Resonance Imaging (MRI) is a well-established imaging tool for the detection and local staging of soft-tissue tumors. MR imaging exhibited different advantages like determining the origin of these lesion in defining their extent and relation to adjacent structures, assessing operability by identifying osseous, neurovascular bundles and joint space involvement by soft tissue tumors. This would help provide a non-invasive diagnosis of such lesions, consequently improving patient management.