Background: Intra-ventricular hemorrhage (IVH), also known as intra-ventricular bleeding, is a bleeding into the brain's ventricular system, where the cerebrospinal fluid is produced and circulates through towards the subarachnoid space. It can result from physical trauma or from hemorrhaging in stroke. It is a significant finding in a neonatal intensive care incubator's babies with sudden onset of anemia. It attracts our attention to the importance of this issue & its burden complication in the future.  Subject & method: We report a case of full term male baby aged 10 days, delivered by caesarean section who was admitted to neonatal intensive care unit (NICU) with fits & transient apnea. Bedside trans-cranial ultrasound is the main tool of investigation in NICU. Conventional therapy centers on managing hypertension and intracranial pressure while correcting coagulopathy and avoiding complications such as re-bleeding and hydrocephalus.   Result: There is an association between neonatal anemia & occurrence of spontaneous intra-ventricular hemorrhage. Conclusion: IVH may be a devastating complication of anemia & bedside trans-cranial ultrasound is a valuable tool in detecting the degree of intra-ventricular hemorrhage and so patient outcome.