Background: Prostatic carcinoma (PCa) represents the second most common cancer, and the fifth leading cause of cancer death among males worldwide. PSCA is a GPI-anchored cell surface protein. It belongs to the Thy-1/Ly-6 family which shows a functional diversity ranging from T-cell activation to apoptosis regulation. Snail is one of zinc finger proteins which are transcriptional repressors of E-cadherin. Aim: To study PSCA and Snail expression in different prostatic lesions to evaluate their roles in PCa. Material and Methods: This retrospective study was done upon 80 different prostatic lesions; 17 cases of BPH, 13 cases of HGPIN, and 50 cases of PCa. PSCA and Snail immunostaining was done and assessed for each case. Results: There was a highly significant statistical correlation between both PSCA and Snail expressions and histopathological type (P-value<0.01). PSCA expression showed a highly significant statistical correlation with Gleason score, tumor grade and stage (P-value<0.01), and a significant correlation with PSA, and peri-neural invasion (P-value<0.05). Snail expression showed a highly significant statistical correlation with Gleason score and tumor grade (P-value<0.01), and a significant correlation with lymph node metastasis and tumor stage (P-value<0.05). There was a highly significant statistical correlation between PSCA and Snail immune-expression (P-value<0.01). Conclusion: PSCA and Snail expressions correlate with the most important prognostic clinicopathological variables in PCa, thus they may represent a useful predictor of prognosis.