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231629

Interleukin-4, and interferon-gamma roles as biomarkers in Systemic Lupus Erythematosus patients.

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Disease pathology
Endocrinology, Hematology, Metabolic diseases

Abstract

Abstract:


Objective: To evaluate interleukin-4 (IL-4), and interferon-gamma (IFN-γ) levels in Systemic lupus erythematosus (SLE) cases in addition to evaluating the correlation of IFN-γ, and IL-4 with disease activity. Patients and Methods: This study recruited 60 adult SLE subjects and 60 healthy controls. Subjects underwent complete clinical examination, history taking, as well as evaluation of disease activity in cases with SLE via the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Determination of serum levels of IFN-γ, and IL-4 was done in controls as well as patients. Results: IFN-γ, and IL-4 levels were substantially elevated in the SLE cohort than in the controls. Furthermore, the IFN-γ level is significantly positively correlated with SLEDAI, with no link between SLEDAI as well as IL-4. Conclusion: Elevated IFN-γ and IL-4 serum levels in cases with SLE play a role in SLE progression and have a role in disease activity. IFN-γ serum levels were positively linked with disease activity and anti-dsDNA, negatively linked with C4, and no significant correlation with C3 and 24 h protein in the urine.

DOI

10.21608/smj.2022.131134.1314

Keywords

Keywords: Systemic lupus erythematosus, interleukin-4, interferon-gamma

Authors

First Name

Asmaa

Last Name

Mostafa

MiddleName

Tarazan

Affiliation

Assistant Lecturer of Clinical and Chemical Pathology-Faculty of medicine- Sohag University.

Email

asmaatarazan@yahoo.com

City

sohag

Orcid

-

First Name

Amany

Last Name

Abd Allah

MiddleName

Abbass

Affiliation

Lecturer of Clinical and Chemical Pathology-Faculty of medicine-Sohag University.

Email

amany_mohamed@med.sohag.edu.eg

City

sohag

Orcid

-

First Name

Sahar

Last Name

Abd Alwahed

MiddleName

Abo alfotoh

Affiliation

Assistant Professor of Clinical and Chemical Pathology-Faculty of medicine-Sohag University.

Email

sahar.fatooh09@gmail.com

City

sohag

Orcid

-

First Name

Rania

Last Name

Hafez

MiddleName

-

Affiliation

Associate Professor of Clinical hematology and bone marrow transplant -Internal medicine department -faculty of medicine-Assiut University.

Email

raniahafez@aun.edu.eg

City

assiut

Orcid

-

First Name

Safenaz

Last Name

Hussien

MiddleName

-

Affiliation

Assistant Professor of Clinical hematology and bone marrow transplant -Internal medicine department -Faculty of medicine-Assiut University.

Email

safenazhussein@aun.edu.eg

City

assiut

Orcid

-

First Name

Rania

Last Name

Bakry

MiddleName

Mohamed

Affiliation

Professor of Clinical Pathology-South Egypt Cancer Institute-Assiut University.

Email

rbakry.md@gmail.com

City

assiut

Orcid

-

Volume

26

Article Issue

1

Related Issue

29548

Issue Date

2022-01-01

Receive Date

2022-04-04

Publish Date

2022-01-01

Page Start

51

Page End

59

Print ISSN

1687-8353

Online ISSN

2682-4159

Article File

SMJ_Volume 26_Issue 1_Pages 51-59.pdf

PDF . 953.5kB

Link

https://smj.journals.ekb.eg/article_231629.html

Detail API

https://smj.journals.ekb.eg/service?article_code=231629

Order

8

Type

Original Article

Type Code

785

Publication Type

Journal

Publication Title

Sohag Medical Journal

Publication Link

https://smj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023