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231600

Interleukin 17 role as a biomarker in Systemic Lupus Erythematosus patients.

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Disease pathology
Endocrinology, Hematology, Metabolic diseases

Abstract

Abstract:

Objective: The purpose of this study is to determine the interleukin 17 (IL-17) level in cases with Systemic lupus erythematosus (SLE), in addition to assessing the correlation of IL-17 with the activity of the disease. Patients and Methods: The present research recruited 60 adult SLE cases versus 60 healthy subjects serving as controls. Subjects had a full clinical evaluation, history taking as well as evaluation of disease activity in cases with SLE via the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). The serum level of IL-17 was measured in controls as well as SLE patients. Results: The IL-17 levels were substantially elevated in the SLE cohort than in controls. In addition, its level was positively related to SLEDAI. Conclusion: The present study findings revealed maximized IL-17 levels in SLE cases, denoting their contribution to the activity as well as the pathogenesis of the disease. Serum IL-17 levels were significantly positively related to the activity of the disease, 24 h protein in the urine, and anti-dsDNA.

DOI

10.21608/smj.2022.131003.1313

Keywords

Systemic lupus erythematosus, Interleukin-17, disease activity

Authors

First Name

Asmaa

Last Name

Mostafa

MiddleName

Tarazan

Affiliation

Assistant Lecturer of Clinical and Chemical Pathology-Faculty of medicine- Sohag University.

Email

asmaatarazan@yahoo.com

City

sohag

Orcid

-

First Name

Amany

Last Name

Abd Allah

MiddleName

Abbass

Affiliation

Lecturer of Clinical and Chemical Pathology-Faculty of medicine-Sohag University.

Email

amany_mohamed@med.sohag.edu.eg

City

sohag

Orcid

-

First Name

Sahar

Last Name

Abd Alwahed

MiddleName

Abo alfotoh

Affiliation

Assistant Professor of Clinical and Chemical Pathology-Faculty of medicine-Sohag University.

Email

sahar.fatooh09@gmail.com

City

sohag

Orcid

-

First Name

Rania

Last Name

Hafez

MiddleName

-

Affiliation

Associate Professor of Clinical hematology and bone marrow transplant -Internal medicine department -faculty of medicine-Assiut University.

Email

raniahafez@aun.edu.eg

City

assiut

Orcid

-

First Name

Safenaz

Last Name

Hussien

MiddleName

-

Affiliation

Assistant Professor of Clinical hematology and bone marrow transplant -Internal medicine department -Faculty of medicine-Assiut University.

Email

safenazhussein@aun.edu.eg

City

assiut

Orcid

-

First Name

Rania

Last Name

Bakry

MiddleName

Mohamed

Affiliation

Professor of Clinical Pathology-South Egypt Cancer Institute-Assiut University.

Email

rbakry.md@gmail.com

City

assiut

Orcid

-

Volume

26

Article Issue

1

Related Issue

29548

Issue Date

2022-01-01

Receive Date

2022-04-03

Publish Date

2022-01-01

Page Start

42

Page End

50

Print ISSN

1687-8353

Online ISSN

2682-4159

Article File

SMJ_Volume 26_Issue 1_Pages 42-50.pdf

PDF . 764.0kB

Link

https://smj.journals.ekb.eg/article_231600.html

Detail API

https://smj.journals.ekb.eg/service?article_code=231600

Order

7

Type

Original Article

Type Code

785

Publication Type

Journal

Publication Title

Sohag Medical Journal

Publication Link

https://smj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023