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229554

Updates Regarding Neurocircuits and Neurotransmitters Involved in the Regulation of Wakefulness

Article

Last updated: 22 Jan 2023

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Abstract

Sleep is a universal phenomenon that observed not only in humans but also in birds, fishes and flies even in simpler organisms such as worms also we spend about 8 hours each day in sleep that represents nearly one third of our life. All these observations indicate a physiological importance of sleep. To start the study of sleep mechanism requires at first study the mechanisms, neurocircuits and neurotransmitters involved in promotion of wakefulness. Observation of Von Economo in 1930 of patients affected by “encephalitis lethargica", an epidemic that causes widespread and prolonged sleepiness most of the day, opened the door for the study of the brain regions responsible for wakefulness. Researchers recognized now many brain regions that are responsible for wakefulness and other brain region responsible for the induction of different types of sleep. This review will try to discuss the most recent mechanisms and neural circuits involved in promotion of wakefulness.

DOI

10.21608/smj.2022.114037.1297

Keywords

wakefulness, orexin, neurocircuits

Authors

First Name

Mohammad Ashraf

Last Name

Ali

MiddleName

Ahmad

Affiliation

Department of Medical Physiology, Faculty of Medicine, Sohag University, Sohag, Egypt

Email

ashrafelkhateb@hotmail.com

City

-

Orcid

-

First Name

Hoda

Last Name

Ahmed

MiddleName

Mostafa

Affiliation

Department of Physiology, Faculty of Medicine, Sohag University, Sohag, Egypt.

Email

hodamoghazy@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Mahmoud

MiddleName

Mostafa

Affiliation

Department of Physiology, Faculty of Medicine, Sohag University, Sohag, Egypt.

Email

ahmed_physiology@yahoo.com

City

-

Orcid

-

First Name

Dina

Last Name

Monir

MiddleName

-

Affiliation

Department of Medical Physiology, Faculty of Medicine, Sohag University, Sohag, Egypt

Email

dr_dina_monir@yahoo.com

City

-

Orcid

-

First Name

Rasha

Last Name

Refaie

MiddleName

Abdeen

Affiliation

Physiology department, Faculty of medicine, Sohag University, Sohag Egypt

Email

dr_rasha12@yahoo.com

City

Sohag

Orcid

-

First Name

Khaled

Last Name

Abdelsater

MiddleName

Ahmed

Affiliation

Physiology Department, faculty of medicine, Al-Azhar University Assuit branch, Assuit, Egypt

Email

khaled_71111@yahoo.com

City

-

Orcid

-

Volume

26

Article Issue

1

Related Issue

29548

Issue Date

2022-01-01

Receive Date

2022-02-23

Publish Date

2022-01-01

Page Start

34

Page End

41

Print ISSN

1687-8353

Online ISSN

2682-4159

Article File

SMJ_Volume 26_Issue 1_Pages 34-41.pdf

PDF . 678.7kB

Link

https://smj.journals.ekb.eg/article_229554.html

Detail API

https://smj.journals.ekb.eg/service?article_code=229554

Order

6

Type

Original Article

Type Code

785

Publication Type

Journal

Publication Title

Sohag Medical Journal

Publication Link

https://smj.journals.ekb.eg/

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Article

Created At

22 Jan 2023