The synthetically new illicit drugs which are called New psychoactive substances (NPS) are the calamity of the modern era. Their danger is much more than the natural drugs of abuse and at the same time, they cannot be detected on regular drug screens making diagnosis very difficult. The number of NPS is growing very fast making their detection more complicated. Another challenge is that their health effects are not well studied and cannot be predicted. Synthetic cannabinoids (SCs) are the most prevalent group in all available NPS. One recent member of the SCs group is AB-CHMINACA. This review article summarizes the available data about AB-CHMINACA. The obtained data were summarized under the following subtitles; historical background, chemical structure, classification, physical characters, pharmacokinetics and pharmacodynamics, toxicity, methods of detection, the magnitude of the problem, and the situation in Egypt. The reviewed studies reveal that AB-CHMINACA like other SC substances are considered toxic with high liability for dependence. Most of the available studies are case reports. The available literature is lacking in specific organ pathology and well-structured toxicity studies.