Background: Common Variants in insulin-like binding protein 2 (IGF2BP2) gene to be associated with type 2 diabetes (T2DM) by several genome-wide association studies and replication analyses. This study aimed to determine the association of IGF2BP2 variants rs4402960 and rs1470579 with T2DM in Egyptian people.
Methods: This study involved 50 T2DM patients and 50 control subjects. Genotyping of SNPs in (IGF2BP2) gene (rs1470579) and (rs4402960) variants using Real-time PCR.
Results: In this study, using logistic regression of this additive model of SNP rs4402960, the presence of homozygous variant allele (TT) genotype carries a 3 fold risk of DM with an odds ratio (OR) of 3.28 (p = 0.095), and homozygous variant allele (CC) genotype of SNP rs1470579 carries a 5 fold risk of DM with OR of 5.44 (p = 0.011). Using the dominant model, the two IGF2BP2 variants carry a high risk of DM. Meanwhile, using the recessive model only SNP rs1470579 carries a risk near 3 fold risk of DM.
Conclusions: This study shows that IGF2BP2 susceptibility variants rs4402960 and rs1470579 are associated with T2DM in Egypt.