We addressed the various analgesic strategies for postoperative cardiac pain relief in this study. While opioid-based is traditionally the cornerstone of postoperative analgesia, there's growing evidence to support a multimodal approach to attenuate opioid side effects and decrease the degree of pain scores and to attenuate the length of hospital stay, and to promote improved rehabilitation approaches that include multimodal regimens as a significant component. For the treatment of postoperative pain following cardiac surgery, several methods are available, including intravenous administration of analgesic drugs such as opioids and non-opioids, local anesthetics infiltration, nerve blocks, and neuraxial methods. Traditionally, after surgery, analgesia is given by analgesic administration. However, the administration of acute opioids is linked to several side defects including respiratory distress, sedation, and lethargy, vomiting and nausea, constipation, retentiveness, purities, and ileus. Therefore, doctors use multimodal pain control regimens including non-opioid analgesic medications for superior pain management. In their understanding of pain, Patients had a specific experience that allows for the difference in pain control. For the treatment of postoperative cardiac pain, several different agents (opioid vs. non-opioid), routes (oral, intravenous, neuraxial, regional), and modes (patient-controlled vs.as required) are accessible.