Patients complaining from cough, fever, dyspnea, and severe pneumonia were recorded in Wuhan, China in late December 2019 due to an unkown microbial agent. Virus genome sequencing of the examined patients during this period confirmed the presence of β- CoV strain. This extracted new β-CoV exhibits 88 percent similarity to the series of 2 severe bat-derived acute respiratory syndromes (SARS)-like corona viruses, bat-SL-CoVZC45 and bat-SL-CoVZXC21, and about 50 percent identical to the MERS-CoV series. Later, the International Commission for Virus Classification called the novel β-CoV "SARS-CoV-2." On the eleventh of February 2020, the World Health Organization (WHO) reported another name for the disease caused by the 2019-n CoV: which is Corona Virus Disease (COVID-19). Several complex immune system mechanisms exist against the newly discovered COVID-19. Communication has undergone between different branches of the immune system, but the exact mechanism remained unclear until now. This study helps to clarify COVID-19 molecular immune pathogenesis.