The aim of this investigation was to evaluate the feasibility of a shortened whole breast irradiation schedule with a concomitant boost delivered to the tumor bed once a-week in patients with early breast cancer submitted to conservative surgery. Methods: This study included 48 female patients with early breast cancer who underwent breast conservative surgery. There were two arm of radiation, hypofractionated radiotherapy with concomitant boost (group A) - hypofractionated radiotherapy with sequential boost (group B).
Results: Acute skin toxicity grade 1 (dry desquamation) was (41.67%) in concomitant boost arm and (25.00%) sequential boost arm. late skin toxicity ,grade 0 was (72.73%) in concomitant boost arm and (54.55%) in sequential boost arm and grade 1 was (9.09%) in concomitant boost arm and (31.82%) in sequential boost arm and grade 2 was (18.19) in concomitant boost arm and (13.55%) in sequential boost arm, grade 3 late lung toxicity was (4.17%) in concomitant boost arm and (12.50%) in sequential boost arm, cardiac toxicity in concomitant boost arm (8.33%) and sequential boost arm (16.67%).The ipsilateral lymphedema after 24 months of follow up G2 (4.55%) in concomitant boost arm G3 (4.55%) in in sequential boost arm.
Conclusion: A shortened whole breast irradiation schedule with a weekly concomitant boost may be an alternative option with acceptable toxicity and excellent cosmesis.