The oncogene Bcl-2 is known as a unique gene that plays an important role in the carcinogenesis pathway by blocking apoptosis. Aims: To evaluate the expression of Bcl-2 protein in normal, hyperplastic and neoplastic endometrial tissues. Materials and methods: Eighty three cases including 7 cases of normal endometrial changes, 37 cases of endometrial hyperplasia and 39 cases of endometrial adenocarcinoma were enrolled for this study. The expression of Bcl-2, ER and PR was evaluated by immunohistochemistry using streptavidin-biotin technique. Results: Non-malignant endometrial lesions tend to express significantly higher level of Bc-l2 compared to malignant endometrial lesion(p= 0.014). The expression of glandular Bc-l2 was significantly higher in hyperplasia compared to carcinoma(p=0.006).There was no significant association between Bcl-2 expression and tumors` histological type or stage orgrade. There was a correlation between Bcl-2 expression and ER or PR expression in endometrial carcinoma. Conclusions: Bcl-2 expression might represent a key in understanding the progression of endometrial neoplastic lesions.