Autophagy is a highly conserved protein degradation pathway responsible for removal of damaged organelles, malformed proteins during biosynthesis, and nonfunctional long-lived proteins by lysosome. Autophagy has been divided into three general types depending on the mechanism by which intracellular materials are delivered into lysosome for degradation that is, microautophagy, chaperone mediated
autophagy (CMA), and macroautophagy. Numerous studies reveal autophagy and autophagy related proteins also participate in immune regulation. in this review we summarized current understanding of the roles of autophagy and autophagy proteins in immune regulation.